Research

Research on advanced topics in need of the time hence GenoMed Laboratories & Research Centre (GLRC) intends to conduct research on advanced topics, which have futuristic approach and potential. The innovative abilities of the research students can be enhanced by assigning them or giving topics where they can use latest technique, which will be comparable to any scientifically advanced country. The research in such areas will boost their interest and open doors for future endeavors.  The followings are the areas of Research in GenoMed Laboratories & Research Centre (GLRC).

1. Next Generation Sequencing.

NGS refers to a number of high-throughput sequencing technologies that allow researchers to sequence DNA and RNA much more quickly and cheaply than older technologies (i.e. Sanger sequencing). NGS has revolutionized the study of genomics by helping to characterize the genetic markers associated with diseases. The technology has the potential to transform clinical care by driving drug development that can target those makers. Oncology has been at the forefront of this transformation, as NGS has allowed for rapid and detailed testing of individual patient tumors, enabling doctors to tailor therapies based on their patient’s specific risk and sensitivity profiles.

We offer research in  Next generation, high-throughput sequencing and data analyses includes Whole Genome Sequencing of Humans, Plants, Animals, Bacteria, Viruses and Chloroplast, Whole Exome Sequencing, Total RNA, mRNA, Amplicon Sequencing.

We also offer data analyses services.

2. Precision Medicine.

Clay Christiansen has described precision medicine as disruptive in its ability to drive down health care costs without compromising quality or outcomes. While precision medicine as a health care strategy continues to evolve with early areas of impact on “the triple aim,” significant challenges stand in the way of its fully disruptive potential. In GenoMed Laboratories & Research Centre (GLRC), we explore the current state of precision medicine, its growing ecosystem and the opportunities that lie ahead for health care and research.

Precision medicine is poised to have an impact on patients, health care delivery systems and research participants in ways that were only imagined 15 years ago when the human genome was first sequenced. While discovery using genome-based technologies has accelerated, these have only begun to be adopted into clinical medicine.

Precision medicine is an approach to patient care that allows doctors to select treatments that are most likely to help patients based on a genetic understanding of their disease. This may also be called personalized medicine. The idea of precision medicine is not new, but recent advances in science and technology have helped speed up the pace of this area of research.

Today, when you are diagnosed with cancer, you usually receive the same treatment as others who have same type and stage of cancer. Even so, different people may respond differently, and, until recently, doctors didn’t know why. After decades of research, scientists now understand that patients’ tumors have genetic changes that cause cancer to grow and spread. They have also learned that the changes that occur in one person’s cancer may not occur in others who have the same type of cancer. And, the same cancer-causing changes may be found in different types of cancer.

3. Forensic DNA Typing and Population Genetics.

ICGR intends to work on advance forensic science and source attribution solutions through innovative efforts. Research in Forensic Sciences includes

Mixture deconvolution – resolution of individual DNA profiles in complex mixtures

Portable, rapid DNA analysis – validated human identification analysis

Featured Research and Development Efforts

STRs, MiniSTRs, SNPs Analysis,

Ancestry Informative Markers (AIMs)

Complex mixture resolution

Stronger likelihood ratios for DNA profiles

Deep kinship analysis and stronger paternity index

Geo-sourcing Eco mapping

Predictive genomics

Externally-visible Characteristics (ie eye and hair color)(EVCs)

Biogeographical ancestry

Populations Migrations

Phylogeny Analysis

Data Analysis using different Softwares like GeneMapper, IDX, Mendeley

4. Identification of Drug Resistance Biomarkers.

Scientific Working Group on Molecular Biology (seminar picture)

GenoMed Laboratories & Research Centre (GLRC), Scientific Working Group on Molecular Biology intend to provide full support in all molecular biology procedures, such as

DNA extraction (Organic Method/ Commercially available kit Method)

Polymerase Chain Reaction (PCR), Real Time PCR, Qf-PCR,  Polyacrylamide Gel Electrophoresis, Gel electrophoresis (horizontal, vertical), Size Estimation of DNA Fragment, Nanodrop, UV-visible spectrophotometry (range: 200-1000 nm), Fluorometric enzyme assays, fluorescence–based assays, AlphaImager Protein Simple (Gel documentation system) (chemiluminescence, DNA quantification, bacterial colony counting, protein gel documentation), Southern and Western Blotting, Primer designing, Sanger sequencing, Phylogenetic studies, Evolutionary studies (evolutionary analysis, Y-Micro deletion Fragment Analysis,  Genetics analysis/genotyping, Molecular marker development, High Resolution Melt (HRM) analysis (detects mutations/variations in DNA/RNA samples, Plasmid Preparation etc.

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